Uric acid is the metabolic end product of “Purine” of nucleic acid in vivo. 80% of blood uric acids come from the breakdown of amino acids and ribosomes, while 20% of them derive from the metabolism of food containing purine or nuclear proteins. Most of the uric acid is formed by purine in the liver, filtered out by the kidneys and passes out of the body in urine. Excessive uric acid formation or under excretion of uric acid by the kidney may both lead to hyperuricemia, gouty arthritis, and gout.
The diagnostic criteria for uric acid
| Blood uric acid level | Men | Women |
| Desired | < 7 mg/dl | < 7 mg/dl |
| Hyperuricemia | > 7 mg/dl | > 7 mg/dl |
90% of patients are primary hyperuricemia, which the high uric acid level is primarily caused either by genetic contributors or underexcretion of uric acid by the kidney. 10% of the patients have secondary hyperuricemia, which is caused by other disorders, including obesity, hyperlipidemia, renal failure, or medications. Gout is a type of hyperuricemia caused by the failure of high-purine metabolism, resulting in the accumulation of sodium urate in articular cavities and leads to joint swelling and deformity.
Patients with gout should drink more than 2000ml water per day to facilitate the metabolism of uric acid, avoid fried and high-fat food, avoid drinking due to the metabolism of alcohol may produce lactic acid and thus impede the excretion of uric acid, and increase the consumption of dietary fibers.
